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20 thg 10, 2024 · RCTD 通过整合单细胞和空间转录组学数据，能够较为精确地为空间点（spots）分配细胞类型或细胞类型的混合，以便更好地理解空间组织结构中的基因表达情况。
18 thg 2, 2021 · Spatial mapping of cell types with RCTD enables the spatial components of cellular identity to be defined, uncovering new principles of cellular organization in biological tissue.
8 thg 5, 2020 · Here, we develop Robust Cell Type Decomposition (RCTD, mkdynamics.com.vn/dmcable/RCTD), a computational method that leverages cell type profiles learned from single-cell RNA sequencing data to decompose mixtures, such as those observed in spatial transcriptomic technologies.
RCTD learns cell type profiles from the scRNA-seq dataset, and uses these to label the spatial transcriptomics pixels as cell types. RCTD has been tested across a variety of spatial transcriptomics technologies including imaging-based (e.g. MERFISH) and sequencing-based (e.g. Slide-seq, Visium).
19 thg 11, 2022 · 稳健细胞类型分解 (Robust Cell Type Decomposition，简称RCTD)是一种从空间转录组数据中学习细胞类型的统计方法。 在本次示例中，我们将为小脑Slide-seq数据集反卷积注释细胞类型。
Spatial mapping of cell types with RCTD enables defining spatial components of cellular identity, uncovering new principles of cellular organization in biological tissue. RCTD is publicly available as an open source R package at mkdynamics.com.vn/dmcable/RCTD.
11 thg 3, 2025 · Robust Cell Type Decomposition (RCTD) is a statistical method for decomposing cell type mixtures in spatial transcriptomics data. In this vignette, we will use a simulated dataset to demonstrate how you can run RCTD on spatial transcriptomics data and visualize your results.
28 thg 3, 2025 · Robust Cell Type Decomposition (RCTD) is a statistical method for decomposing cell type mixtures in spatial transcriptomics data. In this vignette, we will use a simulated dataset to demonstrate how you can run RCTD on spatial transcriptomics data and visualize your results.
RCTD inputs a spatial transcriptomics dataset, which consists of a set of pixels, which are spatial locations that measure RNA counts across many genes. RCTD additionally uses a single cell RNA …
6 thg 4, 2025 · RCTD是一种将单细胞RNA测序数据中的细胞类型注释转移到空间转录组学数据的方法，通过整合两种数据，能精确为空间spots分配细胞类型，帮助理解空间组织结构中的基因表达情况。
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